Compound Detail
CHEMBL236201
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
C[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CC[C@@H]2[C@H](O)c1cccc2ccccc12
Basic Information
| ChEMBL ID | CHEMBL236201 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FWLWRHKXDGEBTC-KZQOYIJHSA-N |
2
Targets
5
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
424.5
MW (Da)
6.25
ALogP
3
HBA
1
HBD
38.0
PSA (Ų)
0.42
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 7.5
IC50 1 meas. best 8.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 8.19 | 8.19 | 6.4 | 1 |
| Glucocorticoid receptor CHEMBL2034 | EC50 | 7.5 | 7.04 | 32.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 6.4 | nM | 8.19 | Displacement of [3H]dexamethasone from human glucocorticoid receptor alpha | 17467988 |
| Glucocorticoid receptor | EC50 | = | 32.0 | nM | 7.5 | Activity at human glucocorticoid receptor in C57BI/6 mouse peritoneal exudate ce... | 17467988 |
| Glucocorticoid receptor | EC50 | = | 33.0 | nM | 7.48 | Activity at human glucocorticoid receptor in human A549 cells assessed as repres... | 17467988 |
| Glucocorticoid receptor | EC50 | = | 94.0 | nM | 7.03 | Activity at human glucocorticoid receptor in C2C12 cells assessed as mouse gluta... | 17467988 |
| Glucocorticoid receptor | EC50 | = | 703.0 | nM | 6.15 | Activity at human glucocorticoid receptor in human HepG2 cells assessed as tyros... | 17467988 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17467988 | 10.1016/j.bmcl.2007.03.103 | Glucocorticoid receptor | 8 |
| 17467988 | 10.1016/j.bmcl.2007.03.103 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine