Compound Detail
CHEMBL2371059
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CNc1ccc(C(C(C)C)[C@@H]2NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(N)=O)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC2=O)cc1
Basic Information
| ChEMBL ID | CHEMBL2371059 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OCRLCDWARWMSOX-YHCHFURVSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
1356.6
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 4 CHEMBL1853 | IC50 | 8.64 | 8.64 | 2.3 | 1 |
| Somatostatin receptor type 3 CHEMBL2028 | IC50 | 6.96 | 6.96 | 110.0 | 1 |
| Somatostatin receptor type 2 CHEMBL1804 | IC50 | 6.89 | 6.89 | 130.0 | 1 |
| Somatostatin receptor type 1 CHEMBL1917 | IC50 | 6.49 | 6.49 | 323.0 | 1 |
| Somatostatin receptor type 5 CHEMBL1792 | IC50 | 6.4 | 6.4 | 397.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 4 | IC50 | = | 2.3 | nM | 8.64 | Binding affinity towards human somatostatin receptor type 4 using [125I][Leu8,D-... | 14667214 |
| Somatostatin receptor type 3 | IC50 | = | 110.0 | nM | 6.96 | Binding affinity towards human somatostatin receptor type 3 using [125I][Leu8,D-... | 14667214 |
| Somatostatin receptor type 2 | IC50 | = | 130.0 | nM | 6.89 | Binding affinity towards human somatostatin receptor type 2 using [125I][Leu8,D-... | 14667214 |
| Somatostatin receptor type 1 | IC50 | = | 323.0 | nM | 6.49 | Binding affinity towards human somatostatin receptor type 1 using [125I][Leu8,D-... | 14667214 |
| Somatostatin receptor type 5 | IC50 | = | 397.0 | nM | 6.4 | Binding affinity towards human somatostatin receptor type 5 using [125I][Leu8,D-... | 14667214 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14667214 | 10.1021/jm030245x | Somatostatin receptor type 1 | 1 |
| 14667214 | 10.1021/jm030245x | Somatostatin receptor type 2 | 1 |
| 14667214 | 10.1021/jm030245x | Somatostatin receptor type 3 | 1 |
| 14667214 | 10.1021/jm030245x | Somatostatin receptor type 4 | 1 |
| 14667214 | 10.1021/jm030245x | Somatostatin receptor type 5 | 1 |
Data from ChEMBL 36 via Core Engine