Compound Detail
CHEMBL2371085
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C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O
Basic Information
| ChEMBL ID | CHEMBL2371085 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | WNXUROSSCSHIHM-QSYCSJNNSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
1106.3
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 4 CHEMBL1853 | IC50 | 8.92 | 8.92 | 1.2 | 1 |
| Somatostatin receptor type 3 CHEMBL2028 | IC50 | 8.51 | 8.51 | 3.1 | 1 |
| Somatostatin receptor type 5 CHEMBL1792 | IC50 | 8.05 | 8.05 | 9.0 | 1 |
| Somatostatin receptor type 2 CHEMBL1804 | IC50 | 7.62 | 7.62 | 24.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 4 | IC50 | = | 1.2 | nM | 8.92 | Binding affinity at human Somatostatin receptor type 4 by [125I][Leu8,D-Trp22,Ty... | 14667213 |
| Somatostatin receptor type 3 | IC50 | = | 3.1 | nM | 8.51 | Binding affinity at human Somatostatin receptor type 3 by [125I][Leu8,D-Trp22,Ty... | 14667213 |
| Somatostatin receptor type 5 | IC50 | = | 9.0 | nM | 8.05 | Binding affinity at human Somatostatin receptor type 5 by [125I][Leu8,D-Trp22,Ty... | 14667213 |
| Somatostatin receptor type 2 | IC50 | = | 24.0 | nM | 7.62 | Binding affinity at human Somatostatin receptor type 2 by [125I][Leu8,D-Trp22,Ty... | 14667213 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14667213 | 10.1021/jm0302445 | Somatostatin receptor type 1 | 1 |
| 14667213 | 10.1021/jm0302445 | Somatostatin receptor type 2 | 1 |
| 14667213 | 10.1021/jm0302445 | Somatostatin receptor type 3 | 1 |
| 14667213 | 10.1021/jm0302445 | Somatostatin receptor type 4 | 1 |
| 14667213 | 10.1021/jm0302445 | Somatostatin receptor type 5 | 1 |
Data from ChEMBL 36 via Core Engine