Compound Detail
CHEMBL2375494
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Basic Information
| ChEMBL ID | CHEMBL2375494 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WSCWRSSILDQLBE-RIYZIHGNSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
236.3
MW (Da)
4.06
ALogP
1
HBA
0
HBD
17.1
PSA (Ų)
0.56
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| G-protein coupled receptor 52 CHEMBL3297639 | IC50 | 6.19 | 6.19 | 650.0 | 2 |
| G-protein coupled receptor 52 CHEMBL4105791 | IC50 | 6.19 | 6.19 | 650.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| G-protein coupled receptor 52 | IC50 | = | 650.0 | nM | 6.19 | Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed... | 33185430 |
| G-protein coupled receptor 52 | IC50 | = | 650.0 | nM | 6.19 | In-vivo antagonist activity at GPR52 in HdhQ140 mouse model with GPR52 knockdown... | 33443413 |
| G-protein coupled receptor 52 | IC50 | = | 650.0 | nM | 6.19 | Inhibition of GPR52 (unknown origin) | 36490325 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23611151 | 10.1021/np300815t | Human immunodeficiency virus 1 | 1 |
| 33185430 | 10.1021/acs.jmedchem.0c01133 | G-protein coupled receptor 52 | 1 |
| 33443413 | 10.1021/acs.jmedchem.0c02235 | G-protein coupled receptor 52 | 1 |
| 36490325 | 10.1021/acs.jmedchem.2c00799 | G-protein coupled receptor 52 | 1 |
Data from ChEMBL 36 via Core Engine