Compound Detail
CHEMBL238090
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Basic Information
| ChEMBL ID | CHEMBL238090 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TUWFZAWPLYDRPS-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
367.8
MW (Da)
3.54
ALogP
7
HBA
0
HBD
65.6
PSA (Ų)
0.45
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.01
Ki 1 meas. best 6.99
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 1 CHEMBL3772 | IC50 | 8.01 | 8.01 | 9.8 | 1 |
| Metabotropic glutamate receptor 1 CHEMBL4477 | Ki | 6.99 | 6.99 | 103.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 1 | IC50 | = | 9.8 | nM | 8.01 | Antagonist activity at human mGluR1a expressed in CHO cells assessed by measurin... | 17929793 |
| Metabotropic glutamate receptor 1 | Ki | = | 103.5 | nM | 6.99 | Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thi... | 17929793 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17929793 | 10.1021/jm070590c | Metabotropic glutamate receptor 1 | 2 |
| 17929793 | 10.1021/jm070590c | Metabotropic glutamate receptor 5 | 1 |
Data from ChEMBL 36 via Core Engine