Compound Detail
CHEMBL23812
AZIETOMIDATE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL23812 |
| Name | AZIETOMIDATE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DUOHNSBKYJHAMQ-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
298.4
MW (Da)
3.22
ALogP
6
HBA
0
HBD
68.8
PSA (Ų)
0.77
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.66
IC50 1 meas. best 4.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Xenopus sp. CHEMBL612667 | EC50 | 5.66 | 5.66 | 2200.0 | 1 |
| Nicotinic acetylcholine receptor alpha1/beta1/gamma/delta CHEMBL3038460 | IC50 | 4.6 | 4.6 | 25000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Xenopus sp. | EC50 | = | 2200.0 | nM | 5.66 | Anesthetic activity in Xenopus tadpole measured as loss of righting reflex | 16884293 |
| Nicotinic acetylcholine receptor alpha1/beta1/gamma/delta | IC50 | = | 25000.0 | nM | 4.6 | Inhibition of recombinant embryonic mouse muscle Nicotinic Acetylcholine Recepto... | 12646036 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12646036 | 10.1021/jm020465v | No relevant target | 2 |
| 16884293 | 10.1021/jm051207b | GABA-A receptor; anion channel | 2 |
| 12646036 | 10.1021/jm020465v | Nicotinic acetylcholine receptor alpha1/beta1/gamma/delta | 1 |
| 16884293 | 10.1021/jm051207b | Serotonin 3 (5-HT3) receptor | 1 |
| 16884293 | 10.1021/jm051207b | Xenopus sp. | 1 |
Data from ChEMBL 36 via Core Engine