Assay Detail
Functional
CHEMBL870388
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Anesthetic activity in Xenopus tadpole measured as loss of righting reflex
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus |
| Tissue | Tadpole |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.03 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385026 | — | — | 1 | 6.66 |
| CHEMBL215734 | — | — | 1 | 6.16 |
| CHEMBL23812 | AZIETOMIDATE | — | 1 | 5.66 |
| CHEMBL681 | ETOMIDATE | 4.0 | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385026 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL215734 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL23812 | AZIETOMIDATE | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL681 | ETOMIDATE | EC50 | = | 2300.0 | nM | 5.64 |