Compound Detail
CHEMBL2381255
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Basic Information
| ChEMBL ID | CHEMBL2381255 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FMFMUUUKWLZXTR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
295.4
MW (Da)
2.78
ALogP
6
HBA
0
HBD
57.8
PSA (Ų)
0.73
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 8.44 | 8.44 | 3.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 3.6 | nM | 8.44 | Inhibition of GST-fused human recombinant PI3Kalpha expressed in baculovirus inf... | 23540645 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23540645 | 10.1016/j.bmcl.2013.02.102 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 2 |
Data from ChEMBL 36 via Core Engine