Compound Detail
CHEMBL2381648
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2381648 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | APZIMAYYQKOWFP-OCHAIDQKSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
242.2
MW (Da)
-1.38
ALogP
4
HBA
4
HBD
129.7
PSA (Ų)
0.48
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.47
EC50 1 meas. best 5.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 3 CHEMBL2888 | IC50 | 5.47 | 5.47 | 3390.0 | 1 |
| Metabotropic glutamate receptor 2 CHEMBL5137 | IC50 | 5.3 | 5.3 | 4990.0 | 1 |
| Metabotropic glutamate receptor 6 CHEMBL4573 | EC50 | 5.17 | 5.17 | 6690.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 3 | IC50 | = | 3390.0 | nM | 5.47 | Antagonist activity at human mGlu3 receptor expressed in golden Syrian hamster A... | 23675965 |
| Metabotropic glutamate receptor 2 | IC50 | = | 4990.0 | nM | 5.3 | Antagonist activity at human mGlu2 receptor expressed in golden Syrian hamster A... | 23675965 |
| Metabotropic glutamate receptor 6 | EC50 | = | 6690.0 | nM | 5.17 | Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12... | 23675965 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23675965 | 10.1021/jm4000165 | Metabotropic glutamate receptor 6 | 2 |
| 23675965 | 10.1021/jm4000165 | Metabotropic glutamate receptor 3 | 2 |
| 23675965 | 10.1021/jm4000165 | Metabotropic glutamate receptor 2 | 2 |
| 23675965 | 10.1021/jm4000165 | Metabotropic glutamate receptor 8 | 1 |
Data from ChEMBL 36 via Core Engine