Compound Detail
CHEMBL2385290
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2385290 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FFDPUUZDAMRRCD-LBPRGKRZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
312.3
MW (Da)
0.00
ALogP
6
HBA
2
HBD
121.9
PSA (Ų)
0.79
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.93
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prolyl endopeptidase FAP CHEMBL5769 | IC50 | 4.93 | 4.93 | 11800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prolyl endopeptidase FAP | IC50 | = | 11800.0 | nM | 4.93 | Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-ni... | 24900696 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900696 | 10.1021/ml300410d | Prolyl endopeptidase | 1 |
| 24900696 | 10.1021/ml300410d | Dipeptidyl peptidase 2 | 1 |
| 24900696 | 10.1021/ml300410d | Unchecked | 1 |
| 24900696 | 10.1021/ml300410d | Dipeptidyl peptidase 4 | 1 |
| 24900696 | 10.1021/ml300410d | Prolyl endopeptidase FAP | 1 |
Data from ChEMBL 36 via Core Engine