Compound Detail
CHEMBL2386181
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Basic Information
| ChEMBL ID | CHEMBL2386181 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LKYXOFXGDRTLIJ-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
301.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| ORAI 1/2/3 CHEMBL3038476 | IC50 | 5.11 | 4.99 | 7700.0 | 2 |
| Transient receptor potential cation channel subfamily V member 6 CHEMBL1628465 | IC50 | 4.29 | 4.215 | 51300.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| ORAI 1/2/3 | IC50 | = | 7700.0 | nM | 5.11 | Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Cd2+ influx af... | 23602525 |
| ORAI 1/2/3 | IC50 | = | 13400.0 | nM | 4.87 | Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Ca2+ influx af... | 23602525 |
| Transient receptor potential cation channel subfamily V member 6 | IC50 | = | 51300.0 | nM | 4.29 | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of ... | 23602525 |
| Transient receptor potential cation channel subfamily V member 6 | IC50 | = | 72300.0 | nM | 4.14 | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of ... | 23602525 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23602525 | 10.1016/j.bmc.2013.03.037 | ORAI 1/2/3 | 2 |
| 23602525 | 10.1016/j.bmc.2013.03.037 | Transient receptor potential cation channel subfamily V member 6 | 2 |
Data from ChEMBL 36 via Core Engine