Compound Detail
CHEMBL2386647
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Basic Information
| ChEMBL ID | CHEMBL2386647 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JRWILHWFQCKSTH-GFCCVEGCSA-N |
1
Targets
3
Activities
2
Assay Types
2
PK Parameters
5
Publications
0
Known Names
Molecular Properties
338.4
MW (Da)
2.52
ALogP
6
HBA
2
HBD
93.8
PSA (Ų)
0.76
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.5
Ki 1 meas. best 8.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK1 CHEMBL2835 | Ki | 8.47 | 8.47 | 3.4 | 1 |
| Tyrosine-protein kinase JAK1 CHEMBL2835 | EC50 | 6.5 | 6.395 | 320.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 6.8 | mL.min-1.kg-1 | Homo sapiens |
| CL | 4.2 | mL.min-1.kg-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK1 | Ki | = | 3.4 | nM | 8.47 | Inhibition of recombinant JAK1 (unknown origin) using Val-Ala-Leu-Val-Asp-Gly-Ty... | 23659214 |
| Tyrosine-protein kinase JAK1 | EC50 | = | 320.0 | nM | 6.5 | Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT... | 23659214 |
| Tyrosine-protein kinase JAK1 | EC50 | = | 510.0 | nM | 6.29 | Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT... | 23659214 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23659214 | 10.1021/jm4004895 | Tyrosine-protein kinase JAK1 | 4 |
| 23659214 | 10.1021/jm4004895 | Unchecked | 2 |
| 23659214 | 10.1021/jm4004895 | Hepatocyte | 1 |
| 23659214 | 10.1021/jm4004895 | Liver microsomes | 1 |
| 23659214 | 10.1021/jm4004895 | MDCK | 1 |
Data from ChEMBL 36 via Core Engine