Compound Detail
CHEMBL2402529
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2402529 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AEKJLTZHFXMSBO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names
Molecular Properties
298.4
MW (Da)
1.74
ALogP
8
HBA
2
HBD
104.3
PSA (Ų)
0.89
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4A CHEMBL254 | IC50 | 8.44 | 8.44 | 3.6 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 103.0 | mL.min-1.kg-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4A | IC50 | = | 3.6 | nM | 8.44 | Inhibition of human full length PDE4A4 expressed in baculovirus infected sf21 ce... | 23806553 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23806553 | 10.1016/j.bmcl.2013.05.099 | Liver microsomes | 1 |
| 23806553 | 10.1016/j.bmcl.2013.05.099 | High affinity 3',5'-cyclic-AMP phosphodiesterase 7A | 1 |
| 23806553 | 10.1016/j.bmcl.2013.05.099 | 3',5'-cyclic-AMP phosphodiesterase 4A | 1 |
Data from ChEMBL 36 via Core Engine