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Compound Detail

CHEMBL240277

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CC(C)(C)OC(=O)N1CC[C@@H](Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C1

Basic Information

ChEMBL ID CHEMBL240277
Phase Preclinical
Structure Type MOL
InChI Key OLSABNVWHCBXHI-RSUGUSAISA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

436.5
MW (Da)
-0.14
ALogP
11
HBA
4
HBD
155.1
PSA (Ų)
0.51
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H28N6O6
MW 436.47
Aromatic Rings 2
Heavy Atoms 31
NP-Likeness -0.05

Activity Summary

IC50 1 meas. best 6.42
Ki 1 meas. best 6.03

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL226
IC50 6.42 6.42 380.0 1
Adenosine receptor A1
CHEMBL226
Ki 6.03 6.03 929.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17967536 10.1016/j.bmcl.2007.10.028 Adenosine receptor A1 3
17967536 10.1016/j.bmcl.2007.10.028 Adenosine receptor A2a 1
17967536 10.1016/j.bmcl.2007.10.028 Unchecked 1

Data from ChEMBL 36 via Core Engine