Compound Detail
CHEMBL242131
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Basic Information
| ChEMBL ID | CHEMBL242131 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SLZOGARBQLIHCR-ONEGZZNKSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
444.3
MW (Da)
4.33
ALogP
5
HBA
2
HBD
70.2
PSA (Ų)
0.55
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 6.15 | 6.15 | 704.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.36 | 5.36 | 4389.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 704.0 | nM | 6.15 | Inhibition of human EGFR in presence of 1 mM ATP | 17416531 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 4389.0 | nM | 5.36 | Inhibition of human VEGFR2 in presence of 1 uM ATP | 17416531 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17416531 | 10.1016/j.bmc.2007.03.055 | Epidermal growth factor receptor | 4 |
| 17416531 | 10.1016/j.bmc.2007.03.055 | Vascular endothelial growth factor receptor 2 | 4 |
Data from ChEMBL 36 via Core Engine