Compound Detail
CHEMBL242967
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL242967 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QLWCMBZVQJGYTM-RRMPHLOHSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
338.4
MW (Da)
3.59
ALogP
3
HBA
1
HBD
49.2
PSA (Ų)
0.91
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Kappa-type opioid receptor CHEMBL237 | Ki | 7.33 | 7.33 | 47.0 | 1 |
| Mu-type opioid receptor CHEMBL233 | Ki | 6.8 | 6.8 | 160.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Kappa-type opioid receptor | Ki | = | 47.0 | nM | 7.33 | Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO me... | 17433695 |
| Mu-type opioid receptor | Ki | = | 160.0 | nM | 6.8 | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membran... | 17433695 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17433695 | 10.1016/j.bmc.2007.03.076 | Mu-type opioid receptor | 1 |
| 17433695 | 10.1016/j.bmc.2007.03.076 | Kappa-type opioid receptor | 1 |
| 17433695 | 10.1016/j.bmc.2007.03.076 | Delta-type opioid receptor | 1 |
Data from ChEMBL 36 via Core Engine