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Compound Detail

CHEMBL2431369

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COc1c(/C=C/c2ccc(NS(C)(=O)=O)cc2)cc(-c2ccc[nH]c2=O)cc1C(C)(C)CO

Basic Information

ChEMBL ID CHEMBL2431369
Phase Preclinical
Structure Type MOL
InChI Key NSXXJWCUYQQNQT-JXMROGBWSA-N
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

468.6
MW (Da)
3.86
ALogP
5
HBA
3
HBD
108.5
PSA (Ų)
0.44
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H28N2O5S
MW 468.58
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -0.29

Activity Summary

EC50 3 meas. best 8.52
IC50 1 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Hepatitis C virus
CHEMBL379
IC50 9.0 9.0 1.0 1
Hepatitis C virus
CHEMBL379
EC50 8.52 8.3233 3.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24069953 10.1021/jm401266k Hepatitis C virus 5
24069953 10.1021/jm401266k Caco-2 2

Data from ChEMBL 36 via Core Engine