Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2434101

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Hepatitis C virus isolate Con1 infected in human 2209-23 cells after 72 hrs by luciferase reporter gene assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Cell Type 2209-23
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B.
Schoenfeld RC, Bourdet DL, Brameld KA, Chin E, de Vicente J, Fung A, Harris SF, Lee EK, Le Pogam S, Leveque V, Li J, Lui AS, Najera I, Rajyaguru S, Sangi M, Steiner S, Talamas FX, Taygerly JP, Zhao J.
J Med Chem (2013) 56 : 8163 -8182
PubMed 24069953 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 25 7.85 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2431465 1 9.00
CHEMBL2431466 1 9.00
CHEMBL2431462 1 9.00
CHEMBL2431368 1 8.70
CHEMBL2431362 1 8.70
CHEMBL2431369 1 8.52
CHEMBL2431365 1 8.52
CHEMBL2431372 1 8.40
CHEMBL2431363 1 8.40
CHEMBL2431366 1 8.22
CHEMBL2431367 1 8.22
CHEMBL2431364 1 8.15
CHEMBL2431370 1 8.10
CHEMBL2431373 1 8.10
CHEMBL2431457 1 8.05
CHEMBL2431464 1 7.89
CHEMBL2431467 1 7.60
CHEMBL2431456 1 7.52
CHEMBL2431461 1 7.42
CHEMBL2431463 1 7.28
CHEMBL2431460 1 6.71
CHEMBL2431459 1 6.66
CHEMBL2431458 1 6.56
CHEMBL2431455 1 6.04
CHEMBL2324313 1 5.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2431465 EC50 = 1.0 nM 9.00
CHEMBL2431466 EC50 = 1.0 nM 9.00
CHEMBL2431462 EC50 = 1.0 nM 9.00
CHEMBL2431368 EC50 = 2.0 nM 8.70
CHEMBL2431362 EC50 = 2.0 nM 8.70
CHEMBL2431369 EC50 = 3.0 nM 8.52
CHEMBL2431365 EC50 = 3.0 nM 8.52
CHEMBL2431372 EC50 = 4.0 nM 8.40
CHEMBL2431363 EC50 = 4.0 nM 8.40
CHEMBL2431366 EC50 = 6.0 nM 8.22
CHEMBL2431367 EC50 = 6.0 nM 8.22
CHEMBL2431364 EC50 = 7.0 nM 8.15
CHEMBL2431370 EC50 = 8.0 nM 8.10
CHEMBL2431373 EC50 = 8.0 nM 8.10
CHEMBL2431457 EC50 = 9.0 nM 8.05
CHEMBL2431464 EC50 = 13.0 nM 7.89
CHEMBL2431467 EC50 = 25.0 nM 7.60
CHEMBL2431456 EC50 = 30.0 nM 7.52
CHEMBL2431461 EC50 = 38.0 nM 7.42
CHEMBL2431463 EC50 = 53.0 nM 7.28
CHEMBL2431460 EC50 = 196.0 nM 6.71
CHEMBL2431459 EC50 = 218.0 nM 6.66
CHEMBL2431458 EC50 = 278.0 nM 6.56
CHEMBL2431455 EC50 = 912.0 nM 6.04
CHEMBL2324313 EC50 = 3860.0 nM 5.41