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Compound Detail

CHEMBL2431458

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COc1c(NC(=O)[C@H]2CC[C@H](NS(C)(=O)=O)CC2)cc(-c2ccc[nH]c2=O)cc1C(C)(C)C

Basic Information

ChEMBL ID CHEMBL2431458
Phase Preclinical
Structure Type MOL
InChI Key BEHRTRZQNODLIE-JCNLHEQBSA-N
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

475.6
MW (Da)
3.39
ALogP
5
HBA
3
HBD
117.4
PSA (Ų)
0.59
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H33N3O5S
MW 475.61
Aromatic Rings 2
Heavy Atoms 33
NP-Likeness -1.01

Activity Summary

EC50 2 meas. best 6.56
IC50 1 meas. best 7.64

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Hepatitis C virus
CHEMBL379
IC50 7.64 7.64 23.0 1
Hepatitis C virus
CHEMBL379
EC50 6.56 6.185 278.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24069953 10.1021/jm401266k Hepatitis C virus 3

Data from ChEMBL 36 via Core Engine