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Compound Detail

CHEMBL2432050

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Fc1cccc(CCCN[C@H]2C3C4CC5C6C4CC3C6C52)c1

Basic Information

ChEMBL ID CHEMBL2432050
Phase Preclinical
Structure Type MOL
InChI Key SJWCMFMHVZULSJ-DKSPCFMDSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

297.4
MW (Da)
3.49
ALogP
1
HBA
1
HBD
12.0
PSA (Ų)
0.82
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H24FN
MW 297.42
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness -0.15

Activity Summary

Ki 2 meas. best 8.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Ki 8.05 8.05 9.0 1
Sigma non-opioid intracellular receptor 1
CHEMBL3602
Ki 7.6 7.6 24.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23981939 10.1016/j.bmc.2013.07.045 RAW264.7 7
23981939 10.1016/j.bmc.2013.07.045 Unchecked 5
23981939 10.1016/j.bmc.2013.07.045 Muscarinic acetylcholine receptor M1 1
23981939 10.1016/j.bmc.2013.07.045 Sodium-dependent noradrenaline transporter 1
23981939 10.1016/j.bmc.2013.07.045 Histamine H3 receptor 1
23981939 10.1016/j.bmc.2013.07.045 Histamine H4 receptor 1
23981939 10.1016/j.bmc.2013.07.045 5-hydroxytryptamine receptor 1A 1
23981939 10.1016/j.bmc.2013.07.045 5-hydroxytryptamine receptor 1B 1
23981939 10.1016/j.bmc.2013.07.045 5-hydroxytryptamine receptor 2A 1
23981939 10.1016/j.bmc.2013.07.045 5-hydroxytryptamine receptor 2B 1
23981939 10.1016/j.bmc.2013.07.045 5-hydroxytryptamine receptor 5A 1
23981939 10.1016/j.bmc.2013.07.045 5-hydroxytryptamine receptor 6 1
23981939 10.1016/j.bmc.2013.07.045 5-hydroxytryptamine receptor 7 1
23981939 10.1016/j.bmc.2013.07.045 Muscarinic acetylcholine receptor M2 1
23981939 10.1016/j.bmc.2013.07.045 Muscarinic acetylcholine receptor M3 1
23981939 10.1016/j.bmc.2013.07.045 Muscarinic acetylcholine receptor M4 1
23981939 10.1016/j.bmc.2013.07.045 Muscarinic acetylcholine receptor M5 1
23981939 10.1016/j.bmc.2013.07.045 Delta-type opioid receptor 1
23981939 10.1016/j.bmc.2013.07.045 Kappa-type opioid receptor 1
23981939 10.1016/j.bmc.2013.07.045 Mu-type opioid receptor 1

Data from ChEMBL 36 via Core Engine