Compound Detail
CHEMBL2436173
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Basic Information
| ChEMBL ID | CHEMBL2436173 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HCMMBTOYIMVPBJ-QGZVFWFLSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
374.5
MW (Da)
4.61
ALogP
4
HBA
0
HBD
42.3
PSA (Ų)
0.63
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cellular tumor antigen p53 CHEMBL4096 | EC50 | 7.1 | 7.1 | 80.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cellular tumor antigen p53 | EC50 | = | 80.0 | nM | 7.1 | Activation of p53 in human HT1080-L cells after 16 hrs by luciferase reporter ge... | 24090918 |
| Cellular tumor antigen p53 | EC50 | = | 80.0 | nM | 7.1 | Activation of p53 in human RCC45ConALuc cells after 16 hrs by luciferase reporte... | 24090918 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24090918 | 10.1016/j.ejmech.2013.08.049 | Cellular tumor antigen p53 | 2 |
Data from ChEMBL 36 via Core Engine