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Compound Detail

CHEMBL243690

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CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4c(F)c(F)c(F)c(F)c4C3=O)CC2)CC1

Basic Information

ChEMBL ID CHEMBL243690
Phase Preclinical
Structure Type MOL
InChI Key GFECFRLDYQFMGJ-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

519.5
MW (Da)
4.76
ALogP
5
HBA
0
HBD
53.1
PSA (Ų)
0.25
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H29F4N3O3
MW 519.54
Aromatic Rings 2
Heavy Atoms 37
NP-Likeness -0.85

Activity Summary

Ki 3 meas. best 7.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-1D adrenergic receptor
CHEMBL223
Ki 7.52 7.52 30.2 1
Alpha-1A adrenergic receptor
CHEMBL229
Ki 7.42 7.42 37.8 1
Alpha-1B adrenergic receptor
CHEMBL232
Ki 5.39 5.39 4108.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17254786 10.1016/j.bmcl.2006.12.111 Alpha-1A adrenergic receptor 1
17254786 10.1016/j.bmcl.2006.12.111 Alpha-1B adrenergic receptor 1
17254786 10.1016/j.bmcl.2006.12.111 Alpha-1D adrenergic receptor 1
17254786 10.1016/j.bmcl.2006.12.111 Adrenergic receptors; alpha-1 A & B 1
17254786 10.1016/j.bmcl.2006.12.111 Unchecked 1

Data from ChEMBL 36 via Core Engine