Compound Detail
CHEMBL2440198
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O
Basic Information
| ChEMBL ID | CHEMBL2440198 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | NTWPZMVJPHWOPJ-YUDYGECGSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
748.9
MW (Da)
-3.18
ALogP
10
HBA
14
HBD
352.9
PSA (Ų)
0.03
QED
2
Ro5 Violations
23
Rot. Bonds
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.54
Ki 1 meas. best 6.31
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide Y receptor type 4 CHEMBL4877 | EC50 | 6.54 | 6.54 | 291.0 | 1 |
| Neuropeptide Y receptor type 4 CHEMBL4877 | Ki | 6.31 | 6.31 | 490.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 4 | EC50 | = | 291.0 | nM | 6.54 | Agonist activity at human Y4 receptor expressed in sf9 cells assessed as hydroly... | 24090364 |
| Neuropeptide Y receptor type 4 | Ki | = | 490.0 | nM | 6.31 | Displacement of Cy5-[K4]hPP from human Y4 receptor expressed in CHO cells after ... | 24090364 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24090364 | 10.1021/jm4008505 | Neuropeptide Y receptor type 4 | 3 |
| 24090364 | 10.1021/jm4008505 | Neuropeptide Y receptor type 5 | 1 |
| 24090364 | 10.1021/jm4008505 | Neuropeptide Y receptor type 2 | 1 |
| 24090364 | 10.1021/jm4008505 | Neuropeptide Y receptor type 1 | 1 |
Data from ChEMBL 36 via Core Engine