Compound Detail
CHEMBL2440363
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Basic Information
| ChEMBL ID | CHEMBL2440363 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NVCQLCFDFSLHPE-PXTSUWAFSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
380.4
MW (Da)
5.04
ALogP
3
HBA
1
HBD
51.2
PSA (Ų)
0.61
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 9.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily KQT member 2 CHEMBL2985 | EC50 | 9.05 | 9.05 | 0.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily KQT member 2 | EC50 | = | 0.9 | nM | 9.05 | Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential b... | 24070783 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24070783 | 10.1016/j.bmcl.2013.08.092 | Brain | 2 |
| 24070783 | 10.1016/j.bmcl.2013.08.092 | Potassium voltage-gated channel subfamily KQT member 2 | 2 |
| 24070783 | 10.1016/j.bmcl.2013.08.092 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine