Compound Detail
CHEMBL2440451
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Basic Information
| ChEMBL ID | CHEMBL2440451 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BBTVQUWEONDCQJ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
385.5
MW (Da)
3.37
ALogP
5
HBA
2
HBD
66.7
PSA (Ų)
0.80
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 CHEMBL1875 | Ki | 6.1 | 6.1 | 794.3 | 1 |
| 5-hydroxytryptamine receptor 4 CHEMBL5017 | Ki | 6.1 | 6.1 | 794.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Ki | = | 794.33 | nM | 6.1 | Displacement of [125I]SB207710 from 5-HT4 receptor in guinea pig brain membranes | 24113240 |
| 5-hydroxytryptamine receptor 4 | Ki | = | 794.33 | nM | 6.1 | Displacement of [125I]SB207710 from human recombinant 5-HT4 receptor | 24113240 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24113240 | 10.1016/j.bmc.2013.09.004 | 5-hydroxytryptamine receptor 4 | 2 |
Data from ChEMBL 36 via Core Engine