Assay Detail
Binding
CHEMBL2447593
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Displacement of [125I]SB207710 from 5-HT4 receptor in guinea pig brain membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Acidic biphenyl derivatives: synthesis and biological activity of a new series of potent 5-HT(4) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.80 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2440453 | — | — | 1 | 9.10 |
| CHEMBL356359 | PIBOSEROD | 2.0 | 1 | 8.80 |
| CHEMBL2440452 | — | — | 1 | 7.20 |
| CHEMBL2440451 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2440453 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL356359 | PIBOSEROD | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL2440452 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL2440451 | — | Ki | = | 794.33 | nM | 6.10 |