Compound Detail
CHEMBL2442611
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Basic Information
| ChEMBL ID | CHEMBL2442611 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SVROOPANNREMBA-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
2
PK Parameters
5
Publications
0
Known Names
Molecular Properties
377.4
MW (Da)
1.74
ALogP
7
HBA
2
HBD
133.9
PSA (Ų)
0.38
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 6.34 | 6.34 | 453.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.5833 | hr | Mus musculus |
| T1/2 | 0.1083 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 453.0 | nM | 6.34 | Antiplasmodial activity against Plasmodium falciparum K1 assessed as [3H]-hypoxa... | 24012380 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24012380 | 10.1016/j.bmc.2013.08.006 | Trypanosoma brucei rhodesiense | 2 |
| 24012380 | 10.1016/j.bmc.2013.08.006 | Liver | 1 |
| 24012380 | 10.1016/j.bmc.2013.08.006 | Liver microsomes | 1 |
| 24012380 | 10.1016/j.bmc.2013.08.006 | L6 | 1 |
| 24012380 | 10.1016/j.bmc.2013.08.006 | Plasmodium falciparum | 1 |
Data from ChEMBL 36 via Core Engine