Assay Detail
Functional
CHEMBL2444844
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Antiplasmodial activity against Plasmodium falciparum K1 assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.82 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403091 | — | — | 1 | 9.40 |
| CHEMBL145251 | — | — | 1 | 8.19 |
| CHEMBL2442601 | — | — | 1 | 8.00 |
| CHEMBL2442609 | — | — | 1 | 8.00 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 7.81 |
| CHEMBL2442605 | — | — | 1 | 7.57 |
| CHEMBL2442612 | — | — | 1 | 7.51 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 7.33 |
| CHEMBL2442606 | — | — | 1 | 7.28 |
| CHEMBL358287 | — | — | 1 | 7.08 |
| CHEMBL2442700 | — | — | 1 | 7.07 |
| CHEMBL2442604 | — | — | 1 | 6.49 |
| CHEMBL2442702 | — | — | 1 | 6.48 |
| CHEMBL2442603 | — | — | 1 | 6.39 |
| CHEMBL2442610 | — | — | 1 | 6.34 |
| CHEMBL2442611 | — | — | 1 | 6.34 |
| CHEMBL2442701 | — | — | 1 | 6.11 |
| CHEMBL2442602 | — | — | 1 | 6.06 |
| CHEMBL2442608 | — | — | 1 | 5.25 |
| CHEMBL2442613 | — | — | 1 | 5.15 |
| CHEMBL2442614 | — | — | 1 | 5.13 |
| CHEMBL2442607 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403091 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL145251 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL2442601 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2442609 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL2442605 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2442612 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 46.4 | nM | 7.33 |
| CHEMBL2442606 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL358287 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL2442700 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL2442604 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL2442702 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL2442603 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2442610 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL2442611 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL2442701 | — | IC50 | = | 785.0 | nM | 6.11 |
| CHEMBL2442602 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL2442608 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2442613 | — | IC50 | = | 7010.0 | nM | 5.15 |
| CHEMBL2442614 | — | IC50 | = | 7390.0 | nM | 5.13 |
| CHEMBL2442607 | — | IC50 | = | 8400.0 | nM | 5.08 |