Compound Detail
CHEMBL2442612
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Basic Information
| ChEMBL ID | CHEMBL2442612 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DTOBVUKBRPKDPP-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
318.3
MW (Da)
1.17
ALogP
6
HBA
4
HBD
151.3
PSA (Ų)
0.42
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 7.51 | 7.51 | 31.0 | 1 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | IC50 | 7.43 | 7.43 | 37.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 31.0 | nM | 7.51 | Antiplasmodial activity against Plasmodium falciparum K1 assessed as [3H]-hypoxa... | 24012380 |
| Trypanosoma brucei rhodesiense | IC50 | = | 37.0 | nM | 7.43 | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 assesse... | 24012380 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24012380 | 10.1016/j.bmc.2013.08.006 | Trypanosoma brucei rhodesiense | 2 |
| 24012380 | 10.1016/j.bmc.2013.08.006 | L6 | 1 |
| 24012380 | 10.1016/j.bmc.2013.08.006 | Plasmodium falciparum | 1 |
| 24012380 | 10.1016/j.bmc.2013.08.006 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine