Compound Detail
CHEMBL2443063
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Basic Information
| ChEMBL ID | CHEMBL2443063 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VUSLIHPWGMCAFY-QGZVFWFLSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
501.3
MW (Da)
5.23
ALogP
4
HBA
2
HBD
71.0
PSA (Ų)
0.59
QED
2
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.78
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily M member 8 CHEMBL1075319 | IC50 | 7.78 | 7.78 | 16.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily M member 8 | IC50 | = | 16.6 | nM | 7.78 | Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition... | 24055075 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24055075 | 10.1016/j.bmc.2013.08.031 | Transient receptor potential cation channel subfamily A member 1 | 1 |
| 24055075 | 10.1016/j.bmc.2013.08.031 | Transient receptor potential cation channel subfamily V member 4 | 1 |
| 24055075 | 10.1016/j.bmc.2013.08.031 | Transient receptor potential cation channel subfamily V member 3 | 1 |
| 24055075 | 10.1016/j.bmc.2013.08.031 | Transient receptor potential cation channel subfamily V member 1 | 1 |
| 24055075 | 10.1016/j.bmc.2013.08.031 | Transient receptor potential cation channel subfamily M member 8 | 1 |
Data from ChEMBL 36 via Core Engine