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Compound Detail

CHEMBL244906

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Cc1nonc1COc1ccc(CC(C)NCC(O)c2cc(O)cc(O)c2)cc1

Basic Information

ChEMBL ID CHEMBL244906
Phase Preclinical
Structure Type MOL
InChI Key PZPZRVXQQPCERC-UHFFFAOYSA-N
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

399.4
MW (Da)
2.62
ALogP
8
HBA
4
HBD
120.9
PSA (Ų)
0.43
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H25N3O5
MW 399.45
Aromatic Rings 3
Heavy Atoms 29
NP-Likeness -0.44

Activity Summary

EC50 2 meas. best 6.96
IC50 1 meas.

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL5414
EC50 6.96 6.31 110.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17845020 10.1021/jm0704595 Beta-2 adrenergic receptor 4
17845020 10.1021/jm0704595 Liver microsomes 1

Data from ChEMBL 36 via Core Engine