Compound Detail
CHEMBL245385
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Basic Information
| ChEMBL ID | CHEMBL245385 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LHXZVZVBMWAIBJ-FVRDMJKUSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
382.4
MW (Da)
1.38
ALogP
5
HBA
2
HBD
104.0
PSA (Ų)
0.82
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gamma-secretase CHEMBL2094135 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gamma-secretase | IC50 | = | 2.0 | nM | 8.7 | Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 ... | 17502137 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17502137 | 10.1016/j.bmcl.2007.04.082 | Gamma-secretase | 1 |
Data from ChEMBL 36 via Core Engine