Compound Detail
CHEMBL247252
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Basic Information
| ChEMBL ID | CHEMBL247252 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KFCVIOJQUCKOOW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
395.4
MW (Da)
5.27
ALogP
5
HBA
3
HBD
106.1
PSA (Ų)
0.39
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiopoietin-1 receptor CHEMBL4128 | IC50 | 6.74 | 6.74 | 182.0 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | IC50 | 6.35 | 6.35 | 446.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiopoietin-1 receptor | IC50 | = | 181.97 | nM | 6.74 | Inhibition of human Tie2 by HTRF method | 17276055 |
| Vascular endothelial growth factor receptor 1 | IC50 | = | 446.68 | nM | 6.35 | Inhibition of human VEGFR2 by HTRF method | 17276055 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17276055 | 10.1016/j.bmcl.2006.12.077 | Angiopoietin-1 receptor | 1 |
| 17276055 | 10.1016/j.bmcl.2006.12.077 | Vascular endothelial growth factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine