Compound Detail
CHEMBL247642
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Basic Information
| ChEMBL ID | CHEMBL247642 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IAPQCGYOOKRAMC-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
409.4
MW (Da)
4.87
ALogP
6
HBA
2
HBD
79.8
PSA (Ų)
0.49
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thrombopoietin receptor CHEMBL1864 | EC50 | 6.4 | 6.4 | 400.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thrombopoietin receptor | EC50 | = | 400.0 | nM | 6.4 | Agonist activity at human TPOr expressed in BaF3 cells by reporter assay | 17707640 |
| Thrombopoietin receptor | EC50 | = | 400.0 | nM | 6.4 | Agonist activity at TPO receptor | 18396041 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17707640 | 10.1016/j.bmcl.2007.07.038 | Thrombopoietin receptor | 3 |
| 17707640 | 10.1016/j.bmcl.2007.07.038 | Erythropoietin receptor | 1 |
| 17707640 | 10.1016/j.bmcl.2007.07.038 | Granulocyte colony-stimulating factor receptor | 1 |
| 18396041 | 10.1016/j.bmcl.2008.03.052 | Thrombopoietin receptor | 1 |
Data from ChEMBL 36 via Core Engine