Assay Detail
Functional
CHEMBL926798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at TPO receptor
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 44 | 6.42 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408853 | — | — | 1 | 7.50 |
| CHEMBL247606 | — | — | 1 | 7.50 |
| CHEMBL247645 | — | — | 1 | 7.48 |
| CHEMBL263109 | — | — | 1 | 7.24 |
| CHEMBL428226 | — | — | 1 | 7.22 |
| CHEMBL393087 | — | — | 1 | 7.08 |
| CHEMBL247644 | — | — | 1 | 7.06 |
| CHEMBL405683 | — | — | 1 | 7.05 |
| CHEMBL260846 | — | — | 1 | 7.00 |
| CHEMBL249063 | — | — | 1 | 7.00 |
| CHEMBL247822 | — | — | 1 | 7.00 |
| CHEMBL399357 | — | — | 1 | 6.85 |
| CHEMBL247431 | — | — | 1 | 6.77 |
| CHEMBL258532 | — | — | 1 | 6.75 |
| CHEMBL393268 | — | — | 1 | 6.64 |
| CHEMBL405478 | — | — | 1 | 6.58 |
| CHEMBL428227 | — | — | 1 | 6.58 |
| CHEMBL245993 | — | — | 1 | 6.55 |
| CHEMBL247643 | — | — | 1 | 6.54 |
| CHEMBL247642 | — | — | 1 | 6.40 |
| CHEMBL249061 | — | — | 1 | 6.38 |
| CHEMBL246619 | — | — | 1 | 6.38 |
| CHEMBL248237 | — | — | 1 | 6.31 |
| CHEMBL247818 | — | — | 1 | 6.29 |
| CHEMBL409504 | — | — | 1 | 6.28 |
| CHEMBL409092 | — | — | 1 | 6.28 |
| CHEMBL405203 | — | — | 1 | 6.27 |
| CHEMBL399136 | — | — | 1 | 6.24 |
| CHEMBL249062 | — | — | 1 | 6.21 |
| CHEMBL246618 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408853 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL247606 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL247645 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL263109 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL428226 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL393087 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL247644 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL405683 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL260846 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL249063 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL247822 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL399357 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL247431 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL258532 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL393268 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL405478 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL428227 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL245993 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL247643 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL247642 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL249061 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL246619 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL248237 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL247818 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL409504 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL409092 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL405203 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL399136 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL249062 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL246618 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL262855 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL247607 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL260089 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL245994 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL246617 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL247013 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL261539 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL261023 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL248035 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL400559 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL398286 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL248006 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL412807 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL246616 | — | EC50 | > | 10000.0 | nM | - |