Compound Detail
CHEMBL261023
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Basic Information
| ChEMBL ID | CHEMBL261023 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MYAAMOSMVGVCBY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
194.2
MW (Da)
2.53
ALogP
3
HBA
1
HBD
38.9
PSA (Ų)
0.76
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thrombopoietin receptor CHEMBL1864 | EC50 | 5.17 | 5.17 | 6800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thrombopoietin receptor | EC50 | = | 6800.0 | nM | 5.17 | Agonist activity at TPO receptor | 18396041 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18396041 | 10.1016/j.bmcl.2008.03.052 | Thrombopoietin receptor | 1 |
| 25559643 | 10.1021/jm501402x | Apical membrane antigen 1 | 1 |
Data from ChEMBL 36 via Core Engine