Compound Detail
CHEMBL24773
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Basic Information
| ChEMBL ID | CHEMBL24773 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WTFFYZGCISALRI-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
202.3
MW (Da)
0.89
ALogP
5
HBA
0
HBD
44.0
PSA (Ų)
0.73
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.84
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Regulator of G-protein signaling 4 CHEMBL1795091 | IC50 | 7.84 | 7.84 | 14.4 | 1 |
| Glycogen synthase kinase-3 beta CHEMBL262 | IC50 | 4.16 | 4.16 | 70000.0 | 2 |
| Regulator of G-protein signaling 8 CHEMBL2034803 | IC50 | 4.08 | 4.08 | 83500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Regulator of G-protein signaling 4 | IC50 | = | 14.4 | nM | 7.84 | Inhibition of RGS4 interaction with Galpha0 protein by flow cytometry protein in... | 22368763 |
| Glycogen synthase kinase-3 beta | IC50 | = | 70000.0 | nM | 4.16 | Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta | 11881998 |
| Glycogen synthase kinase-3 beta | IC50 | = | 70000.0 | nM | 4.16 | Inhibition of GSK3beta | 22368763 |
| Regulator of G-protein signaling 8 | IC50 | = | 83500.0 | nM | 4.08 | Inhibition of RGS8 interaction with Galpha0 protein by flow cytometry protein in... | 22368763 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22368763 | 10.1021/ml200263y | Unchecked | 2 |
| 11881998 | 10.1021/jm011020u | Glycogen synthase kinase-3 beta | 1 |
| 22368763 | 10.1021/ml200263y | Regulator of G-protein signaling 4 | 1 |
| 22368763 | 10.1021/ml200263y | Regulator of G-protein signaling 8 | 1 |
| 22368763 | 10.1021/ml200263y | Muscarinic acetylcholine receptor M3 | 1 |
| 22368763 | 10.1021/ml200263y | No relevant target | 1 |
| 22368763 | 10.1021/ml200263y | Glycogen synthase kinase-3 beta | 1 |
Data from ChEMBL 36 via Core Engine