Compound Detail
CHEMBL253811
NORDEXFENFLURAMINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL253811 |
| Name | NORDEXFENFLURAMINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MLBHFBKZUPLWBD-ZETCQYMHSA-N |
3
Targets
7
Activities
2
Assay Types
1
PK Parameters
8
Publications
0
Known Names
Molecular Properties
203.2
MW (Da)
2.60
ALogP
1
HBA
1
HBD
26.0
PSA (Ų)
0.79
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 6 meas. best 7.8
Ki 1 meas. best 7.95
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2B CHEMBL1833 | Ki | 7.95 | 7.95 | 11.2 | 1 |
| 5-hydroxytryptamine receptor 2B CHEMBL1833 | EC50 | 7.8 | 7.68 | 15.8 | 4 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | EC50 | 7.6 | 7.6 | 25.1 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | EC50 | 6.7 | 6.7 | 199.5 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| F | 85.0 | % | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37584406 | 10.1021/acs.jmedchem.3c01178 | 5-hydroxytryptamine receptor 2B | 4 |
| 22037049 | 10.1016/j.bmc.2011.10.007 | Trace amine-associated receptor 1 | 2 |
| 17870541 | 10.1016/j.bmc.2007.08.060 | Homo sapiens | 1 |
| 18095642 | 10.1021/jm0709034 | 5-hydroxytryptamine receptor 2C | 1 |
| 18095642 | 10.1021/jm0709034 | 5-hydroxytryptamine receptor 2A | 1 |
| 18095642 | 10.1021/jm0709034 | 5-hydroxytryptamine receptor 2B | 1 |
| 18095642 | 10.1021/jm0709034 | Serotonin 2 receptors; 5-HT2a & 5-HT2c | 1 |
| 18095642 | 10.1021/jm0709034 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine