Compound Detail
CHEMBL256424
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CN(CCO)c1cc2c(cc1C#Cc1ccc(F)cc1)NC(=O)CC(c1cccc(-n3ccnc3)c1)=N2
Basic Information
| ChEMBL ID | CHEMBL256424 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CHIPHPDGPBIINM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
493.5
MW (Da)
4.30
ALogP
6
HBA
2
HBD
82.8
PSA (Ų)
0.41
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 CHEMBL2851 | IC50 | 6.85 | 6.85 | 140.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | IC50 | = | 140.0 | nM | 6.85 | Displacement of [3H]LY354740 from rat recombinant mGluR2 expressed in CHO cells | 18096387 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18096387 | 10.1016/j.bmcl.2007.12.005 | Metabotropic glutamate receptor 2 | 2 |
Data from ChEMBL 36 via Core Engine