Compound Detail
CHEMBL258054
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Basic Information
| ChEMBL ID | CHEMBL258054 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JWRFJKHYBQZYIN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
403.4
MW (Da)
4.89
ALogP
4
HBA
2
HBD
58.0
PSA (Ų)
0.61
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 CHEMBL4794 | IC50 | 8.96 | 8.96 | 1.1 | 1 |
| Transient receptor potential cation channel subfamily V member 1 CHEMBL5102 | IC50 | 7.37 | 7.37 | 43.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | IC50 | = | 1.1 | nM | 8.96 | Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition... | 18299195 |
| Transient receptor potential cation channel subfamily V member 1 | IC50 | = | 43.0 | nM | 7.37 | Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition o... | 18299195 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18299195 | 10.1016/j.bmcl.2008.02.022 | Transient receptor potential cation channel subfamily V member 1 | 2 |
Data from ChEMBL 36 via Core Engine