Compound Detail
CHEMBL258436
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C/C(=N\OCC(C)C)c1ccc2c(c1)c1c3c(c4c(c1n2C(C)C)CCc1nn(C)cc1-4)C(=O)NC3
Basic Information
| ChEMBL ID | CHEMBL258436 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WBNNWMOEDXYOBE-VTNSRFBWSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
483.6
MW (Da)
5.51
ALogP
6
HBA
1
HBD
73.4
PSA (Ų)
0.30
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 8.7 | 7.995 | 2.0 | 2 |
| Angiopoietin-1 receptor CHEMBL4128 | IC50 | 7.34 | 7.34 | 46.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 2.0 | nM | 8.7 | Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM... | 18308565 |
| Angiopoietin-1 receptor | IC50 | = | 46.0 | nM | 7.34 | Inhibition of human recombinant TIE2 by HTRF assay | 18308565 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 51.0 | nM | 7.29 | Inhibition of human recombinant VEGFR2 by HTRF assay | 18308565 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18308565 | 10.1016/j.bmcl.2008.02.001 | Vascular endothelial growth factor receptor 2 | 2 |
| 18308565 | 10.1016/j.bmcl.2008.02.001 | Angiopoietin-1 receptor | 1 |
Data from ChEMBL 36 via Core Engine