Compound Detail
CHEMBL258437
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Basic Information
| ChEMBL ID | CHEMBL258437 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GOPWMXCRSJOJRB-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
328.4
MW (Da)
3.06
ALogP
3
HBA
2
HBD
62.7
PSA (Ų)
0.52
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.8 | 7.8 | 16.0 | 1 |
| Angiopoietin-1 receptor CHEMBL4128 | IC50 | 5.89 | 5.88 | 1300.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 16.0 | nM | 7.8 | Inhibition of VEGFR2 | 18343109 |
| Angiopoietin-1 receptor | IC50 | = | 1300.0 | nM | 5.89 | Inhibition of human recombinant TIE2 by HTRF assay | 18308565 |
| Angiopoietin-1 receptor | IC50 | = | 1357.0 | nM | 5.87 | Inhibition of TIE2 | 18343109 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18308565 | 10.1016/j.bmcl.2008.02.001 | Angiopoietin-1 receptor | 1 |
| 18343109 | 10.1016/j.bmcl.2008.02.069 | Angiopoietin-1 receptor | 1 |
| 18343109 | 10.1016/j.bmcl.2008.02.069 | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine