Compound Detail
CHEMBL25922
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Basic Information
| ChEMBL ID | CHEMBL25922 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BHKMWAQSROIMFF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
238.2
MW (Da)
0.35
ALogP
8
HBA
2
HBD
131.5
PSA (Ų)
0.57
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 CHEMBL330 | Ki | 6.43 | 6.43 | 370.0 | 1 |
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 6.16 | 6.16 | 700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | Ki | = | 370.0 | nM | 6.43 | In vitro inhibition of the specific binding of [3H]Gly to N-methyl-D-aspartate g... | 8632440 |
| Glutamate receptor ionotropic, AMPA | Ki | = | 700.0 | nM | 6.16 | In vitro inhibition of the specific binding of [3H]AMPA to Ionotropic glutamate ... | 8632440 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8632440 | 10.1021/jm950304+ | Glutamate receptor ionotropic, AMPA | 1 |
| 8632440 | 10.1021/jm950304+ | Glutamate receptor ionotropic, NMDA 1 | 1 |
Data from ChEMBL 36 via Core Engine