Compound Detail
CHEMBL260455
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Basic Information
| ChEMBL ID | CHEMBL260455 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IQWHZSNUOSRCCB-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
353.3
MW (Da)
3.67
ALogP
5
HBA
1
HBD
72.2
PSA (Ų)
0.78
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 CHEMBL2851 | IC50 | 6.22 | 6.22 | 608.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | IC50 | = | 608.0 | nM | 6.22 | Displacement of [3H]LY354740 from rat mGluR2 | 18374569 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18374569 | 10.1016/j.bmcl.2008.02.076 | Metabotropic glutamate receptor 2 | 2 |
Data from ChEMBL 36 via Core Engine