Compound Detail
CHEMBL262017
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CC(C)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccccc2)CSSC[C@H](C(=O)N[C@H](C=O)[C@@H](C)O)NC1=O
Basic Information
| ChEMBL ID | CHEMBL262017 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | KBXJEGQBFLLJFL-ILNSAXFWSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
1031.3
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 2 CHEMBL1804 | Ki | 8.77 | 8.77 | 1.7 | 1 |
| Somatostatin receptor type 5 CHEMBL1792 | Ki | 7.88 | 7.88 | 13.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 2 | Ki | = | 1.7 | nM | 8.77 | Binding affinity towards somatostatin receptor type 2 | 16220980 |
| Somatostatin receptor type 5 | Ki | = | 13.1 | nM | 7.88 | Binding affinity towards somatostatin receptor type 5 | 16220980 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16220980 | 10.1021/jm050376t | Somatostatin receptor type 1 | 1 |
| 16220980 | 10.1021/jm050376t | Somatostatin receptor type 2 | 1 |
| 16220980 | 10.1021/jm050376t | Somatostatin receptor type 3 | 1 |
| 16220980 | 10.1021/jm050376t | Somatostatin receptor type 4 | 1 |
| 16220980 | 10.1021/jm050376t | Somatostatin receptor type 5 | 1 |
Data from ChEMBL 36 via Core Engine