Compound Detail

CHEMBL263429

DISOMOTIDE

🧪 Phase II

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🧪 Phase II

CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL263429
Name	DISOMOTIDE
Phase	Phase II
Structure Type	BOTH
InChI Key	BDQMCYCLZBSYJZ-BBXCZNCNSA-N

Known Names

Disomotida Disomotide Gp-100:209-217(210m) peptide Gp100:209-217(210m) peptide MPS-22

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Molecular Properties

1035.2

MW (Da)

Drug Information

Molecule Type	Protein
Chirality	Single Enantiomer

USAN Stem	-tide
USAN Year	2005

Extended Properties

Molecular Formula	C47H74N10O14S
MW	1035.23

Indications

Melanoma Melanoma Uveal Melanoma

Activity Summary

IC50 1 meas. best 7.72

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
HLA class I histocompatibility antigen, A alpha chain CHEMBL2632	IC50	7.72	7.72	19.1	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
HLA class I histocompatibility antigen, A alpha chain	IC50	=	19.1	nM	7.72	MHC class I HLA-A*0201 binding affinity assayed by based inhibition of binding o...	11606121

Literature References

PubMed	DOI	Target Context	# Activities
11606121	10.1021/jm010021j	HLA class I histocompatibility antigen, A alpha chain	1

Data from ChEMBL 36 via Core Engine