Compound Detail
CHEMBL266951
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COc1c(OCc2ccccc2)c(OCc2ccccc2)cc2c1-c1c(cc(OCc3ccccc3)c(OCc3ccccc3)c1OC)C[N+]1(C2)Cc2cc(OCc3ccccc3)c(OCc3ccccc3)c(OC)c2-c2c(cc(OCc3ccccc3)c(Oc3ccccc3)c2OC)C1
Basic Information
| ChEMBL ID | CHEMBL266951 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PIWMTCPUMDWSHW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1329.6
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 4.82 | 4.82 | 15000.0 | 1 |
| Protein kinase C (PKC) CHEMBL2094266 | IC50 | 4.06 | 4.06 | 87000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 15000.0 | nM | 4.82 | Inhibition of c-AMP dependent kinase (PKA) catalytic subunit | 8289196 |
| Protein kinase C (PKC) | IC50 | = | 87000.0 | nM | 4.06 | Inhibitory activity against protein kinase C of rat brain | 8289196 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8289196 | 10.1021/jm00027a025 | Protein kinase C (PKC) | 2 |
| 8289196 | 10.1021/jm00027a025 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine