Compound Detail
CHEMBL267337
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL267337 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YQUZVFNVNWKCTR-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names
Molecular Properties
514.7
MW (Da)
3.95
ALogP
6
HBA
6
HBD
132.7
PSA (Ų)
0.11
QED
2
Ro5 Violations
16
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 7.44 | 7.44 | 36.0 | 1 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | IC50 | 6.5 | 6.5 | 316.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 36.0 | nM | 7.44 | Antiplasmodial activity against Plasmodium falciparum K1 in [3H]hypoxanthine inc... | 18247550 |
| Trypanosoma brucei rhodesiense | IC50 | = | 316.0 | nM | 6.5 | In vitro antitrypanosomal activity against Trypanosoma brucei rhodesiense | 15084128 |
| Trypanosoma brucei rhodesiense | IC50 | = | 316.0 | nM | 6.5 | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 | 18247550 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16759117 | 10.1021/jm060295c | Trypanosoma brucei brucei | 4 |
| 18247550 | 10.1021/jm7013088 | Unchecked | 3 |
| 15084128 | 10.1021/jm031024u | L6 | 2 |
| 16759117 | 10.1021/jm060295c | Trypanosoma brucei | 2 |
| 15084128 | 10.1021/jm031024u | Trypanosoma brucei rhodesiense | 1 |
| 16759117 | 10.1021/jm060295c | Nucleic Acid | 1 |
| 16759117 | 10.1021/jm060295c | Trypanosoma brucei rhodesiense | 1 |
| 18247550 | 10.1021/jm7013088 | Trypanosoma brucei rhodesiense | 1 |
| 18247550 | 10.1021/jm7013088 | Plasmodium falciparum | 1 |
| 18247550 | 10.1021/jm7013088 | L6 | 1 |
Data from ChEMBL 36 via Core Engine