Compound Detail
CHEMBL270041
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Basic Information
| ChEMBL ID | CHEMBL270041 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QOVZQINZWUSANF-UHFFFAOYSA-N |
1
Targets
6
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
309.4
MW (Da)
6.04
ALogP
1
HBA
1
HBD
29.1
PSA (Ų)
0.56
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 4.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sterol O-acyltransferase 1 CHEMBL2782 | IC50 | 4.19 | 4.19 | 64600.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sterol O-acyltransferase 1 | IC50 | = | 64600.0 | nM | 4.19 | Inhibition of human ACAT1 expressed in insect Hi5 cells | 18284184 |
| Sterol O-acyltransferase 1 | IC50 | = | 65000.0 | nM | 4.19 | Inhibition of ACAT1 (unknown origin) | - |
| Sterol O-acyltransferase 1 | IC50 | = | 65000.0 | nM | 4.19 | Inhibition Assay: Methods for assessing the selectively of ACAT1 inhibitors are ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18284184 | 10.1021/jm701474c | Sterol O-acyltransferase 1 | 2 |
| 18284184 | 10.1021/jm701474c | Sterol O-acyltransferase 2 | 2 |
Data from ChEMBL 36 via Core Engine