Compound Detail
CHEMBL271233
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Basic Information
| ChEMBL ID | CHEMBL271233 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FFFWFVRMWPALDL-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
373.4
MW (Da)
3.26
ALogP
6
HBA
1
HBD
111.4
PSA (Ų)
0.54
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transcription factor p65 CHEMBL5533 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transcription factor p65 | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear tran... | 18024113 |
| Unchecked | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of NF-kappaB activation | 19726185 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18024113 | 10.1016/j.bmcl.2007.10.100 | NF-kappa-B inhibitor alpha | 2 |
| 18024113 | 10.1016/j.bmcl.2007.10.100 | Transcription factor p65 | 2 |
| 18024113 | 10.1016/j.bmcl.2007.10.100 | Unchecked | 1 |
| 18024113 | 10.1016/j.bmcl.2007.10.100 | NON-PROTEIN TARGET | 1 |
| 19726185 | 10.1016/j.bmcl.2009.08.021 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine